gracilariopsis persica, from persian gulf, contains bioactive sterols.
نویسندگان
چکیده
gracilariopsis persica (rhodophyta) is one of the most abundant algae, introduced newly from the indian ocean. in this study, the main sterols of the algae have been isolated and identified. separation and purification of the compounds was carried out on silica gel and sephadex lh20 column chromatography (cc) and high performance liquid chromatography (hplc) to obtain five pure compounds 1-5. structural elucidation of the compounds was based on the data obtained from h-nmr, 13c-nmr, dept and mass spectroscopy. the separated compounds from gp. persica were identified as 22-dehydrocholesterol (1), cholesterol (2), stigmasterol (3), β-sitosterol (4) and fucosterol (5) based on the spectral data compared to those reported in literatures. most of these sterols are noteworthy for their effectiveness in decreasing the plasma cholesterol, glucose and inflammation. the results of brine shrimp cytotoxicity assay indicated that the ethyl acetate extract of gp. persica showed a high cytotoxic effect against a. salina nauplii (lc50 = 4 μg/ml). the methanol extract was no effective but the aqueous methanol extract was moderately effective (lc50 = 40 μg/ml) compared to berberine hydrochloride as a positive control (lc50 = 26 μg/ml).
منابع مشابه
Gracilariopsis persica from Persian Gulf Contains Bioactive Sterols
Gracilariopsis Persica (Rhodophyta) is one of the most abundant algae, introduced newly from the Indian Ocean. In this study, the main sterols of the algae have been isolated and identified. Separation and purification of the compounds was carried out on silica gel and sephadex LH20 column chromatography (CC) and high performance liquid chromatography (HPLC) to obtain five pure compounds 1-5. S...
متن کاملGracilariopsis persica, from Persian Gulf, Contains Bioactive Sterols.
Gracilariopsis Persica (Rhodophyta) is one of the most abundant algae, introduced newly from the Indian Ocean. In this study, the main sterols of the algae have been isolated and identified. Separation and purification of the compounds was carried out on silica gel and sephadex LH20 column chromatography (CC) and high performance liquid chromatography (HPLC) to obtain five pure compounds 1-5....
متن کاملGracilariopsis persica, from Persian Gulf, Contains Bioactive Sterols.
Gracilariopsis Persica (Rhodophyta) is one of the most abundant algae, introduced newly from the Indian Ocean. In this study, the main sterols of the algae have been isolated and identified. Separation and purification of the compounds was carried out on silica gel and sephadex LH20 column chromatography (CC) and high performance liquid chromatography (HPLC) to obtain five pure compounds 1-5....
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Implication for health policy/practice/research/medical education: It provides recent information regarding active marine natural products which can be utilized in pharmacy and medicine. Copyright © 2014, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Published by DOCS. This is an open-access article distributed under the terms of the Creative Commons Attribution License,...
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Arizona State University, which discovered the compound. The promise of these and other possible disease-fighting compounds beneath the ocean's surface emphasizes the importance of protecting biodiversity. Many environmental groups have turned their attention to oceans because human activities are harming the seas. Some of these activities include wetlands destruction, overfishing, discharge of...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۳، صفحات ۸۴۵-۸۴۹
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